Pittsburgh Pirates at St. Louis Cardinals odds, picks and predictions


The Pittsburgh Pirates and St. Louis Cardinals lift the lid on the new season when they meet Thursday at Busch Stadium for a 4:15 p.m. ET first pitch. Let’s analyze Tipico Sportsbook‘s lines around the Pirates vs. Cardinals odds with MLB picks and predictions.

Season series: The Cardinals won last year’s season series 12-7.

The Pirates got off to a solid start last season with a 12-13 run in April. But they finished with 101 losses (61-101) and finished last in the NL Central.

The Cardinals played .639 ball (46-26) after the All-Star break last season. They took second place in the NL Central and earned an NL Wild Card berth.

Pirates at Cardinals: Projected starters

RHP JT Brubaker vs. RHP Adam Wainwright

Brubaker (2021: 5-13, 5.36 ERA) gets the ball for the opener. He logged a 1.30 WHIP, 2.8 BB/9, and 9.3 K/9 through 124 1/3 IP last season.

  • Current St. Louis bats own a 1.063 OPS against him.
  • Has logged a 6.01 ERA while allowing an .847 OPS across 18 career road games.

Wainwright (2021: 17-7, 3.05 ERA) counters for the Cards. He clocked a 1.06 WHIP, 2.2 BB/9, and 7.6 K/9 across 206 1/3 IP last season.

  • Logged a 30-inning 0.30 ERA against the Pirates in 2021. Has held current Pittsburgh batters to a whiff-heavy .289 OPS in his career.
  • Owns a career 2.85 ERA at home.

Pirates at Cardinals odds, spread and lines

Lines last updated at 9:15 a.m. ET.

  • Money line: Pirates +145 (bet $100 to win $145) | Cardinals -180 (bet $180 to win $100)
  • Against the spread (ATS): Pirates +1.5 (-140) | Cardinals -1.5 (+115)
  • Over/Under (O/U): 7.5 (O: -130 | U: +105)
Author: Lucy Green