Cleveland Guardians at Kansas City Royals odds, picks and predictions


The Cleveland Guardians open the regular season against the Kansas City Royals Thursday at Kauffman Stadium in Kansas City. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. Royals odds with MLB picks and predictions.

Season series: Guardians won the 2021 regular-season series vs. Royals 14-5, including 8-2 in Kansas City.

It’s a new era of baseball in Cleveland, changing from the Indians to the Guardians. The Royals hope their fortunes change against the Cleveland baseball team, too, as Kansas City really struggled against them in 2021.

The Royals went 74-88 in 2021, including 39-42 at home. But Kansas City was 69-74 against everyone but Cleveland, including 37-34 at home. The Royals also had a dismal run differential of minus-102, compared to just minus-10 for the Guardians in ’21.

Guardians at Royals: Projected starters

RHP Shane Bieber vs. RHP Zack Greinke

Bieber (7-4, 3.17 ERA in 2021) did not factor into the decision in three starts against the Royals in ’21, pitching 15 1/3 innings and striking out 22 batters.

  • Bieber will make his third consecutive Opening Day start, becoming the 12th player in franchise history to work in three or more straight openers.
  • Bieber was actually better on the road in 2021, posting a 5-2 record, 2.91 ERA and .211 OBA in 55 2/3 IP in nine starts.

Greinke (11-6, 4.16 ERA in 2021) posted a 1-0 record, 3.46 ERA and .213 OBA with 12 strikeouts in 13 IP in two starts vs. Cleveland in 2021.

  • Greinke returns to where it all started, as he spent his first seven seasons in the majors from 2004-10 with Kansas City, winning 60 games in 169 starts and 41 relief appearances.
  • Greinke posted a 2-1 record with a 3.44 ERA in six April starts in 2021. That ERA was his lowest month ERA of the entire season.

Guardians at Indians odds, spread and lines

Lines last updated at 12:01 p.m. ET.

  • Money line (ML): Guardians -120 (bet $120 to win $100) | Royals +100 (bet $100 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians -1.5 (+135) | Royals +1.5 (-170)
  • Over/Under (O/U): 7.5 (O: -122 | U: -102)
Author: Lucy Green