Chicago White Sox at Los Angeles Angels odds, picks and predictions


The Los Angeles Angels (36-41) host the Chicago White Sox (35-38) Wednesday at Angel Stadium for the rubber match of their 3-game series finale. First pitch is set for 9:38 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Angels odds with MLB picks and predictions.

L.A. won Monday’s series opener 4-3 and Chicago took Tuesday’s 2nd game 11-4. The season series is tied 3-3, but Chicago has a plus-8 run differential in those meetings.

The Angels are 4-6 straight up (SU) in their last 10 games while the White Sox are 5-5 SU.

White Sox at Angels projected starters

RHP Michael Kopech vs. RHP Shohei Ohtani

Kopech is 2-4 with a 2.59 ERA, 1.01 WHIP, 4.2 BB/9 and 8.2 K/9 in 62 2/3 IP over 13 starts.

  • Last start: Lost 4-1 Friday at home vs. the Baltimore Orioles with 6 IP, 3 ER, 3 H, 4 BB and 2 K.
  • 2022 road splits: 1-2 with a 3.21 ERA (28 IP, 10 ER), 1.25 WHIP, 4 HR and 9.3 K/9 in 6 starts.

Ohtani is 6-4 with a 2.90 ERA, 1.01 WHIP, 2.1 BB/9 and 11.9 K/9 in 68 1/3 IP over 12 starts.

  • Last start: Won 5-0 at home June 22 vs. Kansas City Royals with 8 IP, 0 R, 2 H, 1 BB and 13 K.
  • 2021 vs. the White Sox: One start, a no-decision in L.A.’s 7-4 home win April 4 with 4 2/3 IP, 3 R (1 ER), 2 H, 5 BB and 7 K.

White Sox at Angels odds and lines

  • Money line (ML): White Sox +160 (bet $100 to win $160) | Angels -200 (bet $200 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-140) | Angels -1.5 (+115)
  • Over/Under (O/U): 7.5 (O: -125 | U: +100)

White Sox at Angels picks and predictions


Angels 5, White Sox 3

Money line

LEAN ANGELS (-200) only because we are getting the worst of the number and this is a little out of my price range. Also, I’d entertain throwing L.A.’s ML in a parlay with a similarly priced favorite for a better payout.

That said, this is the best version of Ohtani, the pitcher. Ohtani’s FIP is lower than his ERA (2.90-2.77) and his exit velocity, hard-hit rate, K%, BB% and opposing hitters’ slash line are far better than the MLB average.

Also, L.A.’s lineup outperforms Chicago’s against right-handed pitching in  wRC+ (106-90), wOBA (.316-.291), ISO (.178-.115) and hard-hit rate (30.9-27.2%), per FanGraphs.

The Angels opened at -137 according to but have taken heavy sharp action to get steamed up to the current number.

Since we are getting late to the party on L.A.’s ML, I’d only “FLAT-BET” ANGELS (-200) $20 to win $10, if at all.

Run line/Against the spread

LEAN ANGELS -1.5 (+115) only because I’d prefer parlaying L.A.’s ML with another team for a better payout and betting MLB RLs is tough.

Also, the Angels are just 12-22 RL as home favorites while the White Sox +1.5 (-140) are 13-7 RL as road underdogs despite being just 8-12 SU.

The ANGELS -1.5 (+115) should get there though because L.A. has an edge in the starting pitching and hitting departments and Chicago’s bullpen has regressed into mediocrity this year.



This is a sharp total and I cannot make a convincing argument for either side. White Sox-Angels have an 8-14 O/U record when these starters are on the hill and L.A. is 11-20-3 O/U as home favorites so the Under is the only side of the total I’d consider. But, my numbers have this game going Over.

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Author: Lucy Green